Pankrin™ ELISA

Description

For the in-vitro diagnosis (laboratory diagnosis) of an acute pancreatitis. Because of his high sensitivity the Pankrin™ ELISA is ideal for the fast and reliable diagnosis of an acute pancreatitis in patients who come relatively late to the hospital.

 

In Germany this parametre is exclusively sold and marketed by R-Biopharm AG, Darmstadt

  EU registration number
DE/CA81/IVD1688

Order Code No.:
BS-86-02

Shelf Life:
12 months after date of manufacture

Detailed information on the diagnosis of an acute pancreatitis with the Pankrin™ ELISA

An acute pancreatitis, the acute inflammation of the pancreas, is mostly caused by the dystopic protease activation in the azinus cells, the obstruction of the luminal secretion and the formation of intracellular vacuoles (Schneider 1999). The yearly incidence rate of the acute pancreatitis is 50 to 100 cases per 100.000 persons. The clinical picture of an acute pancreatitis is determined by pronounced abdominal pain and general symptoms like nausea, vomiting, and circulatory collapse (Selberg et al. 1995). The mild form of an acute pancreatitis, the edematous acute pancreatitis (ca. 80% of all cases of an acute pancreatitis) progresses without complications and under adequate therapy patients normally recover within 72 hours. The severe form of an acute pancreatitis, the hemorrhagic necrotizing acute pancreatitis is characterized by necrosis and by a protracted course with frequent failure of organs or organ systems (Asanuma at. al. 1999, Singer et al. 1988). Morphologically a thickening and irregular delimitation of the pancreas can be observed as well as an accumulation of liquid in the pararenal space. The main cause of an acute pancreatitis are an increased alcohol consumption (Blank et al. 1999, Lankisch 2000) and trapped gallstones which possibly get into the pancreatic duct via a reflux (Niederau et al. 1997, UHL et al. 1999, Sharma et al. 1999). Other pathogenetic factors are more rare. In a considerable percentage of the patients suffering from an acute pancreatitis no risk factor can be detected. Cholelithiasis (gallstone disease) peaks between 40 and 60 years, the age maximum for alcohol abusus lies between 20 and 40 years.

Fields of application

In the functional diagnostics of the exocrine pancreas the BIOSERV Pankrin™ ELISA is a sensitive and clinically easily practicable tool ideally complementing the sonographically established initial diagnosis in the diagnosis of an acute pancreatitis.

Sample material:

  • Serum

Literature

  • Lankisch PG, Weber-Dany B, Doobe C, Finger T, Maisonneuve P, Lowenfels AB, Keim V (2006): Pankrin: A new parameter for the diagnosis of acute pancreatitis in cases of late clinical presentation. Pancreas Volume 32/3, pages 330-331.
  • Keim, Volker; Teich, Niels; Bodeker, Hans; Moessner, Joachim (2003): Evaluation of Pankrin™, a new serum test for diagnosis of acute pancreatitis. Clinica Chimica Acta 332, 45 - 50

 

For further inquiries please contact us: info@bioserv-diagnostics.com

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